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Familial Graves’ disease associated with type 1 diabetes.

Filed under Diabet Med, Diabetes by on February 16, 2011 at 10:41 am no comments

Familial Graves' disease associated with type 1 diabetes.

Intern Med. 2009;48(9):701-4

Authors: Matoba K, Tojo K, Nemoto M, Tajima N

A 59-year-old woman was diagnosed as having Graves' disease and type 1 diabetes. DNA molecular HLA typing detected DRB1(*)0405 and DQB1(*)0401, as well as the haplotypes of DRB1(*)0901-DQB1(*)0303. We also performed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to identify allele variations of other loci. The patient's son also manifested Graves' disease and type 1 diabetes, with both cases having strikingly homologous clinical features. Familial clustering of Graves' disease and type 1 diabetes, and their tendency to occur together along with a similar clinical course suggest that their etiology may involve shared genetic factors.

PMID: 19420817 [PubMed - indexed for MEDLINE]

Novel human leukocyte antigen class I and class II alleles identified by sequence-based typing in the Genetics of Kidneys in Diabetes (GoKinD) study population.

Filed under Diabet Med, Diabetes by on February 16, 2011 at 10:41 am no comments

Novel human leukocyte antigen class I and class II alleles identified by sequence-based typing in the Genetics of Kidneys in Diabetes (GoKinD) study population.

Hum Immunol. 2009 Sep;70(9):747-9

Authors: Cordovado SK, Hancock LN, Hendrix M, Greene CN, Mueller PW

Nine novel HLA class I and class II alleles were identified by sequence-based typing (SBT) in Caucasian participants from the Genetics of Kidneys in Diabetes (GoKinD) study. All novel alleles were single nucleotide substitutions. Seven alleles resulted in an amino acid change and two alleles were silent substitutions. The new alleles are as follows: five HLA-A alleles (*0132, *020121, *0344, *030107, *2507), one HLA-C allele (*0619), two HLA-DQB1 alleles (*0204, *0318), and one HLA-DPB1 allele (*1802). Eight of these new alleles were identified in participants with type 1 diabetes, three of whom also had diabetic nephropathy, and one new allele was identified in an unaffected parent of a participant with type 1 diabetes. All new alleles were isolated and characterized by use of single allele amplification (SAA) SBT; the new alleles were confirmed by sequence-specific primer (SSP) amplification.

PMID: 19539002 [PubMed - indexed for MEDLINE]

HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus.

Filed under Diabet Med, Diabetes by on February 16, 2011 at 10:41 am no comments

HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus.

Eur J Ophthalmol. 2009 Jul-Aug;19(4):638-45

Authors: Khazaee MH, Tavakol Afshari J, Khazaee B, Daneshvar R, Akbarzadeh J, Khazaee L, Ganjali R, Raygan F

To investigate if diabetic patients without diabetic retinopathy despite long disease duration have different human leukocyte antigen (HLA) status vs those with an early onset of retinopathy.

PMID: 19551681 [PubMed - indexed for MEDLINE]

Staphylococcus aureus nasal colonization and colonization or infection at other body sites in patients on a burn trauma unit.

Filed under Diabet Med, Diabetes by on February 16, 2011 at 10:40 am no comments

Staphylococcus aureus nasal colonization and colonization or infection at other body sites in patients on a burn trauma unit.

Infect Control Hosp Epidemiol. 2009 Aug;30(8):721-6

Authors: Reighard A, Diekema D, Wibbenmeyer L, Ward M, Herwaldt L

To determine whether Staphylococcus aureus isolates from the nares of patients on a burn trauma unit were related to isolates colonizing or infecting other body sites.

PMID: 19580438 [PubMed - indexed for MEDLINE]

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