Hum Genet. 2010 Jul;128(1):113-7. Epub 2010 May 5.
Rodríguez-Ezpeleta N, Alvarez-Busto J, Imaz L, Regueiro M, Azcárate MN, Bilbao R, Iriondo M, Gil A, Estonba A, Aransay AM.
Genome Analysis Platform, Functional Genomics Unit, CIC bioGUNE, Bizkaia Technology Park, Building 502, 48160, Derio, Spain. nrodriguez@cicbiogune.es
Abstract
A recent study reported that Basques do not constitute a genetically distinct population, and that Basques from Spanish and French provinces do not show significant genetic similarity. These conclusions disagree with numerous previous studies, and are not consistent with the historical and linguistic evidence that supports the distinctiveness of Basques. In order to further investigate this controversy, we have genotyped 83 Spanish Basque individuals and used these data to infer population structure based on more than 60,000 single nucleotide polymorphisms of several European populations. Here, we present the first high-throughput analysis including Basques from Spanish and French provinces, and show that all Basques constitute a homogeneous group that can be clearly differentiated from other European populations.
PMID: 20443121 [PubMed - indexed for MEDLINE]
High levels of inbreeding in East African dairy cattle are a potential concern because of use of a limited range of imported germplasm coupled with strong selection, especially by disease, and sparse performance recording. To address this, genetic relationships and breed composition in an admixed population of Kenyan dairy cattle were estimated by means of a 50K SNP scan. Genomic DNA from 3 worldwide Holstein and 20 Kenyan bulls, 71 putative cow-calf pairs, 25 cows from a large ranch and 5 other Kenyan animals were genotyped for 37 238 informative SNPs. Sires were predicted and 89% of putative dam-calf relationships were supported by genotype data. Animals were clustered with the HapMap population using Structure software to assess breed composition. Cows from a large ranch primarily clust...
Abstract A recent study reported that Basques do not constitute a genetically distinct population, and that Basques from Spanish and
French provinces do not show significant genetic similarity. These conclusions disagree with numerous previous studies, and
are not consistent with the historical and linguistic evidence that supports the distinctiveness of Basques. In order to further
investigate this controversy, we have genotyped 83 Spanish Basque individuals and used these data to infer population structure
based on more than 60,000 single nucleotide polymorphisms of several European populations. Here, we present the first high-throughput
analysis including Basques from Spanish and French provinces, and show that all Basques constitute a homogeneous group that
can be clea...
Conclusions:
These results suggest that a large effective population size (Ne) of approximately 50,000 or more existed in B. taurus since they shared a common ancestor with Bison, Yak and Banteng > 1 million years ago (MYA). More recently Ne decreased sharply probably associated with domestication. This may partially explain the paradox of high levels of polymorphism in Domestic cattle and the relatively small recent Ne in this species. The period of inbreeding caused Fay and Wu's H statistic to depart from its expectation under neutrality mimicking the effect of selection. However, there was also evidence for selection, because high frequency derived alleles tended to cluster near each other on the genome. (Source: BMC Genomics - Latest articles)
