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Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

Filed under Uncategorized by on December 15, 2008 at 1:00 am no comments
Conclusions: The distinct population profile of nonsynonymous variants indicates that natural selection has a significant influence on genomic diversity in P. falciparum, and that many of these changes may reflect functional variants deserving of follow-up study. Our analysis demonstrates the potential for new high-throughput genotyping technologies to enhance studies of population structure, natural selection, and ultimately enable genome-wide association studies in P. falciparum to find genes underlying key phenotypic traits. (Source: Genome Biology)

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